The Kinase Inhibitor Drugs

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Today one of most popular industries is that of biotech and pharmaceutical which has evolved over the ages. This is because each and every day people are facing new complications regarding health; hence the need for the help from pharmaceutical field. This field is vast and varied in nature and encompasses everything from preclinical test to clinical enlargement. Research is being carried in this field for quite a long time and different types of synthetic problems are being solved. The advancement in the technological field is also responsible for the growing trend of regular invention of drugs. Almost everyday new and huge percentage of medicines is being launched in the market which is meant for solving various health related complications. These medicines are meant to solve different kind of diseases through novel means. Pharmaceutical companies in this industry are playing important role and with every passing day they are enhancing the list of drugs. They are constantly trying to launch newer drugs by researching on various molecules thereby trying to solve different types of health hazards.

Kinase inhibitor is the latest molecule which is highly popular and has been able to catch the attention of the researchers. Companies in the field of pharmaceutical research and development are trying to realize is the best dosage to get the exact dosage of each molecule for any specific drug. These kinase inhibitors are important components for cancer related drugs which shows the importance of kinase activity for the development of the anti- cancer drugs. The biotech and pharmaceutical companies carry out analytical studies, physical and chemical characterizations in order to perceive what kind of benefits can be derived from different molecules in order to solve different types of complications.

Recently the research and development companies in the pharmaceutical industry has focused on the tyrosine kinase inhibitors and tried to evaluate its effects that can solve incurable complications. The status of different components like kinase inhibitors are being studied for the maximum utilization in the betterment of the mankind. The scientists and the researchers constantly assist customers in the development of new products which would prove to be helpful in the long run. Discovery and progress are the two parts of this industry and both of these features are being applied in order to get hold of innovative chemical and biological entities.

Apart from kinase activity, there are activities of many other molecules which have attracted the attention of scientists and researchers. Tasocitinib targets a protein called JAK; hence, it is often referred to as a JAK inhibitor. The Pfizer study carried out on JAK trial is expected to bring about a path breaking results in this field. The cancer therapy which is directed towards correcting the problems of molecular alterations has often led to the growth in cancer cells. It has been a part of the treatment of advanced breast cancer and for gastrointestinal tumors. Unlike most novel, target-directed cancer drugs which come with pregenomic traits, this postgenomic natured drug is surely a smart drug capable of fundamentally changing the nature of the treatment of all cancers.

Apart from Tasocitinib, mention should be made about AC220 which is another inhibitor needed for the treatment of acute myeloid leukemia. It has proved to be potent, effective and has the ability to inhibit FLT3. Inhibitor PIK 93 works on the type III PI 4-kinase enzyme selectively. BI- 2536 is another category of potent and selective inhibitor of Polo-like Kinase 1. It has the ability of inhibiting tumor growth in Vivo. PLX4720 is believed to be another important potent which can work in favor of anti- cancer drug research.

Resveratrol Renews Both Body and Spirit

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The modern times brought numerous changes that man never thought could happen 100 years ago. The delicacies are becoming more diverse, and the habits of people are forever changing. Alcohol, fatty foods, cigarettes and other vices brought pleasure to the body but also pushed it to the brink of suffering. Diseases and disorders are continuously spreading, and this has caused alarm to people from all countries and from all walks of life.

Changing one’s habit is easy for some people, but for others it is a hard and painstaking battle. Every day you have to sacrifice just to keep your body healthy by eliminating all the indulgences and vices that once controlled your life. No matter how conscientious you are, you can always use a little assistance from nature. It is a good thing there is an up and coming type of herbal medicine that is all natural and very effective in keeping the body strong and healthy. This product is a supplement made from red wine grape extract.

This is a special product packed with a phytoalexin called Resveratrol. To make things clearer, this active substance is extracted from plants whenever they are under attack by the sun’s radiation, ultraviolet rays and insects. This active substance is commonly found on grape and wine. According to many scientific trials and studies, this herbal product is theoretically 100 wines compressed inside a single bottle of herbal medicine.

Many can testify to the health benefits provided by Resveratrol. According to some studies, this active ingredient can enhance blood circulation, give you better digestive system, and help the cells multiply and recover. In some instances, it was also been proven to prevent cancer and tumors tenfold. Many people where surprised with the health benefits given by this totally natural medicine.

Resveratrol was actively tested on mice and other experiments, and the results where astonishing. The results showed that this byproduct considerably lowered blood sugar levels, prevented cancer cells from spreading, and is a good anti-inflammatory ingredient. Because of this evidence, research companies utilized this active ingredient and replicated it for human consumption. The effects were simply mind-blowing.

Every day more people are using this product because of the health benefits that it provides. History shows that French people, who are fond of drinking wine, lived longer than Americans. This only shows how this grape and wine product has saved and changed the lives of many people. Keep your body strong and healthy and only take the best.

Venapro for relief from Hemorrhoids

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Hemorrhoids may be a result of many things. Primary among them is bad eating habits. When your food lacks fiber content, you will feel that the stool becomes very hard and difficult to pass. You will suffer enormous pain and it may result in bleeding too. Prolonged problem like this will result in Hemorrhoids and they are very painful as well as bleeding. Those who suffer from this problem knows exactly how uncomfortable it is to live with this problem. Furthermore, majority of these sufferers would avoid telling their problem to anyone else, even a doctor!

To help all such people, there is a treatment called Venapro. Let us accept that blood is not a good sight, even if it is a minor injury on your finger. If left unattended, that small injury can cause big problems and Hemorrhoids are not different either. The problem may be invisible to others around you but it would be one of the biggest enemies of your health. So stop being ignorant and embarrassed about your problem and get Venapro.

When I first came to know about this product, I did not want to use it as I had already tried lots of things but in vain. However, a friend of mine recommended it highly and so, I thought about trying it for some time. The first thing I liked about this product was its ingredients that were homeopathic! As I have taken homeopathic treatment before and it was absolutely safe and successful, it gave me boost to try this product immediately. So, I began with this product and kept on using it for some days.

After about 15 days, I could see change in my condition. Pain was decreasing. Yet, it was too early to give any verdict, so I continued using Venapro for another week. Now I could sense that I suffered almost no inflamed skin. Pain was also reduced and I could feel the stool getting softer slowly and it resulted in less blood within a few days. I was happy to see improvements and felt good about myself from inside. I started feeling light and good as I was before I suffered from Hemorrhoids. This motivated me to share my story with lots of other people who suffer from such painful problem silently but are not able to get rid of it. If you are one of them, try Venapro. You will never regret it and your life will never be the same again.

Cholesterol Drugs Are Dangerous And Ineffective

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Over the last 10 to 15 years, the drug companies have gotten so greedy that they are not happy with the profits they are making from ill people, they actually want healthy people to take prescription drugs for “preventative” reasons. One of the most prevalent methods that the have used, and one that makes them several billion dollars a year, is to popularize the fable that the general healthy population will have better health outcomes in the future if they take statin drugs to keep their cholesterol levels low today.

I urge all my readers to do an internet search on this topic, because there are many university professors who disagree with this practice. And now, the proponents of natural therapies and natural prevention have even more research on their side.

The Cochrane Library has published a new study on cholesterol-lowering drugs. What this study found is that almost all studies claiming that cholesterol-lowering drugs are safe have been done by the pharmaceutical companies that sell them. The researchers collected data from 14 such drug trials. The drug trials involved over 34,000 patients. The conclusion was that there is no evidence proving that it is safe for healthy people with no history of heart disease to take cholesterol-lowering drugs.

One of the researchers in the study, Professor Shah Ebrahim from the London school of hygiene and tropical medicine, was quoted as saying that the researchers “found that evidence that potential harm is not being taken seriously. The adverse effects are not included in the trials.”

Furthermore, a study published in the British medical Journal in 2010 concluded that for every heart attack allegedly prevented by cholesterol-lowering drugs, two people suffer liver damage, kidney failure, cataracts or extreme muscle weakness as a direct result of taking the statin drugs. The researchers concluded that statin drugs hurt more people than they help.

The question for the public is what can we do to help ourselves feel and age better without taking dangerous pharmaceutical drugs. The outlook is positive. The most important thing to remember regarding cholesterol is that cholesterol in itself is not a bad thing. Cholesterol is actually the main food for all of the body’s hormones. It is impossible for human beings to function properly, hormonally-speaking, if they are suffering from a lack of cholesterol.

Cholesterol only becomes a problem when there is too much cholesterol going into your blood vessels compared to the amount of cholesterol leaving your blood vessels. This is what the ratio LDL to HDL refers to. If your ratio LDL to HDL is lower than 2 then you should be okay. Even better news is that there is a natural product called concentrated fish oil which actually raises HDL and lowers LDL, thereby improving your ratio with no side effects whatsoever.

Taking 6 capsules of a good-quality concentrated fish oil every day can help balance your lipid profile, including not only cholesterol, but also triglycerides, which are much more conclusively linked to heart disease than cholesterol is. If you combine this with a natural cholesterol-balancing product you can help yourself tremendously and avoid all the dangers of pharmaceutical drugs.

Statin Drug Dangers – And How To Protect Yourself

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In the last five years, I’ve lost count of how many family members or acquaintances of mine have come home from the doctor’s office with a prescription for statins in their hands. There is a good reason for this. Statins, also known as cholesterol-lowering drugs, are a multibillion-dollar annual business. And yet much of this hype is based purely on deception.

A quick search on this topic from the Internet will show that for every university medical study saying that statins reduce the risk of death from heart disease, there is one which says that statins are actually useless and dangerous. Keep in mind one fact: all medical studies are funded by somebody and most of them are actually funded by the pharmaceutical companies that sell the drugs in the studies. Now that is a conflict of interest.

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So what are the dangers of statins? For one thing, statins have been proven to cause damage to the mitochondria, the microscopic, energy-producing organs in our cells. The mitochondria is where the combustion in our bodies takes place. Just like a car burns gasoline, our mitochondria burn food for energy. Damage to the mitochondria is permanent and shortens lifespan. Secondly, statins stop our body’s production of coenzyme Q10. This coenzyme is essential in order for the heart to pump properly. Thirdly, statins are toxic exogenous substances that our bodies cannot process. Statins cause liver damage over time. This is why patients who are on statins are sent to do liver regular check-ups. The doctors know about the dangerous side-effects of statins.

So what can we do about it? There are natural ways to lower the “bad” LDL cholesterol. One of the most effective ways is to take concentrated fish oil capsules at a dose of six capsules per day. Fish oil not only lowers LDL, but it also raises HDL, the so-called good cholesterol, which is the cholesterol as it leaves your blood and goes back to the liver for processing. The fatty acids found in this supplement will also decrease triglycerides, homocysteine and blood pressure, three definite risk factors for heart disease.

Ideally, we should take a concentrated fish oil that also contains ubiquinol, which is coenzyme Q10 in its most absorbable form, and lycopene, a red pigment antioxidant found in tomatoes and which has been shown to protect both the heart and the prostate. There are also some very good-quality natural cholesterol-balancing products on the market today.

Finding a concentrated fish oil supplement that contains absorbable Q10 and is made with fish from the cleanest oceans in the world, far away from pollution and radiation, and taking the corresponding natural supplements, is the most important decision a customer has to make. After a decade of experience, I settled on one specific fish oil made withe clean fish from New Zealand, a product which is both potent, and pure.

Eliminate Body Fat With Proactol

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Are you looking for a natural and organic way to get rid of that unwanted body fat? Are you ready to look good and feel good again? Well, look no further. Proactol is here to help. Proactol is all natural and completely organic and can help you eliminate that body fat you have been carrying around for so long.

Proactol is made from dehydrated cactus leaves. It works by using both a soluble and nonsoluble fiber to help you control the weight you lose and become healthy again. Not only is Proactol a credible weight loss supplement, but it is available over the counter. It is available worldwide and has been approved by the MHRA.

There have been numerous studies to determine the effectiveness of Proactol. Many of the users in these studies lost a great amount of weight without any side effects. Proactol reduces the amount of calories you intake, lowers your appetite and your blood pressure. All of this helps you to get rid of that unwanted body fat.

Body fat can be stubborn and bull headed. However, you don’t have to live with that anymore. The use of the nonsoluble fibers in Proactol allow your body to form a gel around the body fat which doesn’t allow our bodies to absorb the fat. This fat is then processed through our body and eliminated. The use of soluble fibers in Proactol allows your body to slow down it’s digestion time which makes us feel full longer. This allows you to eat less than you would normally.

Proactol is used best when taken after a meal because it can work with the new foods presented to your body. Not many weight loss pills can do what Proactol does. On a greater note, most of the best weight loss pills that do the same as Proactol are only available through a prescription. By the time you pay for the doctor’s visit and the prescription, you have greatly exceeded the amount you would pay for one bottle of Proactol.

With today’s obesity worries and struggles, Proactol could very well be your solution. Using Proactol in a daily routine of diet and exercise can make a great difference in your life. Along with getting plenty of rest, Proactol is a great diet product for those who feel they could shed some unwanted pounds. It is easier than you think and you will feel so much better. Unwanted weight can bring you down in more ways then just by the number on the scale. Improve your self esteem and your weight at the same time.

What Do Vaccines Really Contain?

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Getting the disease for which you receive the vaccine, such as mumps, may actually be a blessing for the afflicted and bestow true immunity to the disease. This may account for some of the disease-preventing effects of vaccines that have been witnessed in a small number of vaccinated individuals. Unfortunately, the vast majority of the vaccinated population doesn’t fall sick. If it did, vaccination could actually have some value. However, if an adjuvant such as aluminum or squalene is added to the vaccine, which is now typical for most vaccines, it can cause your immune system to overreact to the introduction of the organism you are being vaccinated against.

On such occasions, the human body is helpless against the foreign material and is overwhelmed by the antigens and the resulting overreaction of the immune system. This often gives rise to debilitating symptoms (among the agents most often introduced through vaccines is thimerosal, which is linked to neurological damage in the brain), crippling side effects and even life-threatening conditions.

Despite documented evidence that links vaccination to disease and injury, modern medicine insists that vaccines are a type of ‘health insurance’. But just so you know your facts, here is a brief look at what these chemicals contain.

Antigen: At the crux of every vaccine is the disease-causing microorganism or pathogen against which immunity is sought to be induced.

Preservatives: Preservatives are used to increase the shelf-life of a vaccine by preventing bacteria and fungi from invading it. In the US, the FDA allows the use of three preservatives: phenol, 2-phenoxyethanol and thimerosal.

Adjuvants: Adjuvants enhance the body’s immune response immediately after the vaccine is introduced. Though highly dangerous and known to even cause cytokine storms that lead to swift death, pharma companies continue to use adjuvants as ‘boosters’ in their vaccines.

Another compelling reason for the use of adjuvants is that these chemicals, by turbo-charging vaccines, allow drug companies to use less of the antigen in each dose so that they can make more doses. Do the math: More doses means bigger profits.

Aluminum salts are the most widely used adjuvants employed by drug manufacturers. They include: aluminum phosphate, aluminum hydroxide, aluminum hydroxyphosphate sulfate and potassium aluminum sulfateor simply alum.

Till recently, aluminum salts were the only adjuvants vaccine-makers in the US were allowed to use. However, with the FDA toying with the idea of allowing squalene as an adjuvant, there is growing alarm that this chemical, which played havoc with US Gulf War veterans, may be licensed for mass use in the US.

Additives or Stabilizing Agents: Stabilizing agents protect vaccines from getting damaged or losing their efficacy under certain conditions such as freeze-drying and heat. They also prevent the antigen from sticking to the side of the vaccine vial, and the components of the vaccine from separating.

Common additives include sugars such as sucrose and lactose; amino acids such as glycine, monosodium glutamate; and proteins such as gelatin or human serum albumin.

Concerns regarding these additives center around the use of gelatin, human serum albumin and material derived from bovines, especially cows. While gelatin is suspected to precipitate hypersensitivity reactions, human serum albumin (derived from dead human fetuses) could introduce pathogens into the body.

Material taken from cattle came into focus with the outbreak of Bovine Spongiform Encephalopathy or ‘mad cow disease’ in England in the 1980s.

Residual Agents: Residual agents are used during the production process to inactivate the live pathogen and to culture the virus. They are eventually removed from the vaccine, or at least that is what vaccine-makers claim.

Residual agents include bovine serum (a popular agent used to grow the virus in cell cultures); formaldehyde (used as an inactivating agent); and antibiotics such as neomycin, streptomycin and polymyxin B to prevent bacterial contamination.

Animal Products: Animal products are most frequently used in vaccine production as the medium in which the virus is cultured and grown. They perform two essential functions: they provide nutrition to the pathogen and they provide cell lines that help it replicate to make the millions of doses that are then commercially sold.

Animals whose organs, tissues, blood and serum are commonly used to make vaccines are monkeys, cows, sheep, chickens, pigs and occasionally dogs and rabbits.

Human Products: Human fetal cells (human diploid cells) divide indefinitely and are used to make cell lines that make a virus replicate. For instance, the rubella virus is grown in human tissue culture as the virus is incapable of infecting animals.

After a virus is cultured, the pathogen is purified while removing it from the growth culture. However, traces of genetic material from the culture often remain in the vaccine.

This presents a real and ever-present danger. If the host animal or human being is infected, secondary pathogens are likely to be passed on during vaccination.

This is exactly what happened when the polio vaccine, grown in monkey kidney cells, were later found to be contaminated with the Simian Vacuolating Virus 40 or SV40.

Having looked at the broad categories of components in vaccines, here is a list of some toxic agents (with documented side effects) used in their production.

Acetone: Nail polish remover

Oil Adjuvants: A neurotoxin linked to Alzheimer’s disease and seizures. It can also precipitate arthritis

Formaldehyde: A carcinogenic agent used as an embalming fluid

Ethylene Glycol: Antifreeze widely used in car engines

Triton X100: A detergent

Glycerin: Candamage internal organs such as the lungs, liver and kidneys and gastrointestinal tract

Monosodium glutamate (MSG): According to the FDA, MSG Symptom Complex or MSG side effects can result in numbness, burning sensation, tingling, facial pressure or tightness, chest pain, headache, nausea, rapid heartbeat, drowsiness, weakness, and difficulty in breathing for asthmatics. More specifically, studies have shown that MSG can cause arrhythmia, atrial fibrillation, tachycardia, rapid heartbeat, palpitations, slow heartbeat, angina, extreme rise or drop in blood pressure, swelling, diarrhea, nausea/vomiting, stomach cramps, rectal bleeding, bloating, flu-like achiness, joint pain, stiffness, depression, mood swings, rage reactions, migraine headache, dizziness, light-headedness, loss of balance, disorientation, mental confusion, anxiety, panic attacks, hyperactivity, behavioral problems in children, attention deficit disorders, lethargy, sleepiness, insomnia, numbness or paralysis, seizures, sciatica, slurred speech, chills and shakes, shuddering, blurred vision, difficulty focusing, pressure around eyes, asthma, shortness of breath, chest pain, tightness in the chest, runny nose, sneezing, frequent bladder pain, swelling of the prostate, swelling of the vagina, vaginal spotting, frequent urination, nocturia, hives (may be both internal and external), rash, mouth lesions, temporary tightness or partial paralysis, numbness or tingling of the skin, flushing, extreme dryness of the mouth, face swelling, tongue swelling, bags under eyes

Phenol or Carbolic Acid: A lethal toxin used in household and industrial products as a disinfectant as well as a dye

Thimerosal (derivative of mercury): A toxic heavy metal used as a preservative. Closely linked to autism, autoimmune diseases and other neuro-developmental disorders

Aluminum: A metallic element which, besides damaging the brain in children, can also predispose adults to neurological problems such as Alzheimer’s disease and dementia

Polysorbate 80 (Tween80™): An emulsifier that can cause severe allergic reactions, including anaphylaxis. In addition, according to a Slovakian study on rats published in the journal Food and Chemical Toxicology in 1993, Tween80 can lead to infertility. Tween80 accelerated the rats’ maturation, prolonged the estrous cycle, decreased the weight of the uterus and ovaries, and caused damage to the lining of the uterus indicative of chronic estrogenic stimulation.

All this makes me wonder why so many millions of people started to get afflicted with the diseases that are listed as side effects of these toxins after mass vaccinations were introduced into modern societies. Most of these diseases were nearly unheard of before the vaccine-mania began.

A Controversial Drug

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Thalidomide Is Nothing to Fear

Thalidomide has been a controversial drug for over fifty years. In the late 1950’s its antiangiogenic properties cause the deformities in over 12,000 infants around the world. Thalidomide’s initial purpose was to be used as a sedative or sleeping pill. In the years since its release, scientists have found many uses for the drug, including use of its pernicious side effect to inhibit the growth of many cancers. Thalidomide is a highly misunderstood drug with many positive applications. The history of thalidomide’s weaknesses, and strengths, spans over fifty years. Thalidomide was the safer choice than barbiturate sedatives and ironically helpful in relieving morning sickness. Shortly after its release in 1961, thalidomide was link to the deformities around the world, and the sale of thalidomide was stopped worldwide.

In the ensuring years, scientists have continued to explore the characteristics of thalidomide. As scientist began to look for the exact mechanism in thalidomide that was responsible for the birth defects, they would soon discover that thalidomide had numerous uses, and only two side effects. Thalidomide could be used to treat leprosy, soothe pains associated with leprosy. The two side effects experiences from thalidomide have been deformities, and an irreversible tingling sensation in extremities. Thalidomide was the best treatment in relieving pains from arthritis pains to ulcer pains.

Many fear the worst of the drug and do not realize that, every drug has its’ own risks, and every drug label has a warning to pregnant or nursing mothers. It is up to the consumer whether or not to heed the warning, or take a risk. Even with Americans being able to take their own risk, there will be steps taken to minimize the risks.

The FDA will do everything to prevent the repeating of another epidemic. No system is 100% effective, and no drug is 100% safe, but any system of prevention is worth a try. Thalidomide in the 1950’s was extremely underdeveloped and only needed to be refined. More research has been performed on the drug and an explanation for the birth defects has emerged. Knowing how thalidomide works will enable scientist’s to do just the opposite, make it not work. Researchers have produced many analogues, variations, of thalidomide and it is hopeful that they will engineer a form of thalidomide without harmful side effects. The risk of birth defects from thalidomide could be almost zero, and thalidomide will prove to be just what the doctor ordered, and nothing more.

Painkillers – The Beginning of a Vicious Cycle

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Taking painkillers, unless it is absolutely necessary for extremely painful conditions, is an act of suppressing and destroying the healing intelligence of the body. When ill, the body may require pain signals to trigger the appropriate immune response for the removal of toxins from a localized area and to prevent the individual from further harming himself. Pain is not a disease and should therefore not be treated as one. Pain is the body’s natural response to congestion and the subsequent dehydration and malnourishment of the cells and tissues. It occurs in the presence of toxic material and is often accompanied by infection. In most cases, a pain signal occurs when one of the brain’s first aid hormones, called histamine, is secreted in large amounts and passes over the pain nerves near or alongside a congested area.

The body also uses histamines to reject foreign materials such as viral particles or toxic substances and to direct other hormones or systems in the body to regulate water distribution. The latter function of histamine is very important, for where there is a buildup of toxins, there is also an acute water shortage (dehydration). When the pain signal becomes suppressed, however, the body is confused over how it should deal with the congestion and subsequent increase of toxicity. Painkillers also prevent the body from learning about the progressive condition of cellular dehydration. In addition, in order to process painkillers, the cells of the body have to give up even more of their precious water.

Usually, the intensity of pain rises with the concentration of toxins and materials such as blood proteins trapped in the fluid surrounding the cells. This liquid substance is called interstitial fluid or connective tissue, and it is drained by the lymphatic system. When the lymphatic system is congested due to digestive problems or other reasons which I will explain later, the escape route for these blood proteins and toxins is closed. To prevent the immediate destruction of the cells by these highly acidic and reactive proteins and toxins, the body surrounds them with water. This in turn causes further obstruction and prevents the proper oxygenation of the cells. Pain directly results from this lack of oxygen. Research published in December 1964 by one of the earlier journals of the American Medical Association, Today’s Health, proved that blood proteins naturally leave the bloodstream and enter the connective tissues, but if not instantly removed by the lymphatic system, they can cause disease and death in as little as 24 hours.

The body certainly knows about this danger and acts accordingly. The brain produces the perfect amount of natural painkillers, i.e. endorphins(endogenous opioids), in order to keep the pain tolerable but still strong enough to maintain a powerful and active immune and cleansing response. Synthetically derived painkillers on the other hand cause an electrical short circuit of the pain signal. The brain and the immune system, though, need to receive this signal to be able to attend to the endangered area. The sudden suppression of pain can be likened to cutting the wires of an alarm system that is protecting a house. When a burglar enters this house, nobody will notice it. By cutting off its communication with the brain, the body is unable to remove all the trapped toxins and blood proteins, and their destructive effect may go unnoticed. What is so disturbing about taking pharmaceutical drugs, such as pain medication, is that they need blood proteins to carry them to their destinations. Since the blood proteins are trapped in the connective tissues of an organ, these drugs become trapped there, too. This causes the serious side effects and frequent deaths for which these drugs are so well known. The pharmaceutical industry, of course, does not want you to know that by taking their drugs you are gambling with your life.

Pain medications not only keep the body ignorant about a particular physical problem, they also sabotage its healing efforts. The regular use of painkillers suppresses endorphin production in the brain, thereby causing drug dependency. This also lowers the body’s tolerance level for pain, making even minor problems of congestion very painful. Some people have abused their bodies in this way to such an extent that they suffer from excruciating chronic pain, although the causal problem may actually be only a minor one. When painkillers are no longer effective enough, some people may even wish to take their lives to obtain the desired relief.

If you have been on painkillers for arthritis or other painful conditions but now know that taking drugs such as Vioxx, Aleve, Celebrex, and aspirin dramatically increases your risk of heart attack and stroke, you may want to switch to natural alternatives until you have eliminated the root causes of your pain. According to the New England Journal of Medicine, “anti-inflammatory drugs (prescription and over-the-counter medications which include Advil, Motrin, Aleve, Ordus, aspirin, and over 20 others) alone cause over 16,500 deaths and over 103,000 hospitalizations per year just in the U.S.” The amount of five major painkillers sold at retail establishments rose 90 percent between 1997 and 2005, according to an Associated Press analysis of statistics from the Drug Enforcement Administration.

Even the smallest amount of aspirin triggers at least some degree of intestinal bleeding. Regular use of aspirin has serious consequences. Nearly 70 percent of those taking aspirin daily show a blood loss of to 1 teaspoons per day, and 10 percent lose as much as two teaspoons per day.

A recent study published in the Annals of Internal Medicine showed that use of NSAIDs such as aspirin and ibuprofen increased the risk of high blood pressure (HPP) by nearly 40 percent. Similar use of acetaminophen was found to increase HBP risk by 34 percent.

Parents Should Know About Possible Birth Defects From Anticonvulsants

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The FDA released a MedWatch Safety Alert in December 2009 which notified health care professionals and patients about the increased risk of major birth defects in babies exposed to valproate sodium (a sodium salt of valproic acid) during pregnancy, which included the following recommendation: “women who are planning a pregnancy or who become pregnant while taking valproate should contact their health care professionals immediately.” Drugs containing valproic acid compounds include brand names such as Depakote, Depakote ER, Depakene, Depacon, divalproex sodium, Depakote CP and Stavzor

Valproic acid is a chemical compound found in various anticonvulsant medications. Physicians prescribe these drugs for people with seizure disorders, epilepsy, the manic phase of bipolar disorders and migraine headaches. Since its approval by the U.S. Food & Drug Administration (FDA) in 1967, valproic acid and the brand name drug Depakote have proven to be effective in these patients.

However, once a prescription drug is approved, the FDA, independent laboratories and others continue to study its use and any side effects that patients may experience. Over time, additional studies have revealed a potential connection between anticonvulsant drugs taken by pregnant women and a number of serious birth injuries including spina bifida, cleft palate, craniofacial defects, cardiovascular malformations and neural tube birth defects.

The American College of Obstetricians and Gynecologists (ACOG) states that three of every 100 babies in the United States are born with a major birth defect. Many of these birth defects can be treated and even cured, but collectively they are the leading cause of death during the first year of a baby’s life.

In some cases, pregnant women must take drugs such as Depakote to treat their epilepsy. The FDA recommends that these women should consider enrolling in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334 or visiting AEDPregnancyRegistry.org. According to the Registry, there are 16 reported cases of birth defects in newborns of 149 women with epilepsy. They were taking approximately 1,000 mg of valproic acid-based medication per day during the first trimester of their pregnancies. Three of those 16 cases were neural tube defects.

The March of Dimes calculates that caring for a child with a birth defect will cost $140,000 to $170,000 during his or her lifetime. Spina bifida’s lifetime treatment is even more expensive, costing almost $300,000. It is this financial and emotional burden of caring for a child with a major birth injury that may have severe impact on the quality of life for these families for years to come.