High cholesterol is one of the main causes of heart related fatalities in US and around the world. Data shows that one in every 6 adults which translates in to 16.3% of the population of USA is suffering from high cholesterol. The average level of cholesterol of average American is 200 mg/dl which is in the borderline of high risk category. People with high cholesterol are twice as susceptible to have a heart attack than who have healthy levels of cholesterol. There is also the possibility that excess cholesterol is being produced within the body itself due to genetic conditions. For those suffering from such cholesterol conditions, medical intervention followed through with a proper diet and exercise routine is crucial if to avoid future complications. Among cholesterol drugs that helps with controlling cholesterol levels, Zetia10mg and other doses has proven to be versatile. Zetia contains the active ingredient, Ezetimibe which not only reduce the cholesterol, but also reduce other sterols that the body absorbs. Zetia has the benefit of being well tolerated with a combination of other cholesterol-reducing medicines.
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Understanding Cholesterol
It is important to understand what is cholesterol and its role if we are to understand the use of any cholesterol reducing drug. Human body produce some part of the cholesterol while the dietary intakes account for the rest. The liver produces the most cholesterol although the intestine may also produce some small amounts. Cholesterol is important for the proper functioning of the body from making hormones to vitamin D and various enzymes that are used in digesting food. The problem occurs when the level of cholesterol increase beyond what is required. This is especially with regards to the so called bad cholesterol, the LDL cholesterol which contains higher percentage of cholesterol. The HDL or high density lipoprotein cholesterols on the other hand are desirable and help supply the body with desired levels of cholesterol for its functioning. The HDL is responsible for transferring cholesterol from various parts of the body back to the liver from where it is excreted. The LDL on the other hand transfers the cholesterol to the artery walls and deposit it, lending to plaque buildup and narrowing of the arteries. This is the main cause of heart attacks. Therefore, the role of cholesterol reducing drugs is to reduce the level of LDL cholesterol in the body by either blocking the production or blocking the absorption of it from what we eat. Zetia as a drug performs the latter, by its action in the intestines.
How Zetia Works
Zetia contains non-statin substance. Unlike the other types of cholesterol-reducing medicines which work in the liver, Zetia’s action is within the digestive system. The active ingredient Ezetimibe works by inhibiting the absorption of cholesterol at the small intestines. This is achieved through binding with the NPC1L1) protein on the intestine cell walls. There is also a secondary control action where the reduced cholesterol absorption lends to an upregulation of LDL receptors that are present on the cell surface, leading to increased LDL cholesterol uptake to the cells. This in turn reduce the levels of LDL in the blood stream, aiding the effective control of cholesterol levels. For deriving best results, Zetia treatment should be combined with a low-cholesterol diet as well as a statin drug. The medicine takes approximately two weeks from the starting of the medication, to yield a result.